Association of measures of fetal and childhood growth with non-clinical psychotic symptoms in 12-year-olds: the ALSPAC cohort.
Br J Psychiatry
; 194(6): 521-6, 2009 Jun.
Article
em En
| MEDLINE
| ID: mdl-19478292
BACKGROUND: Previous studies have suggested that impaired fetal and childhood growth are associated with an increased risk of schizophrenia, but the association of pre-adult growth with non-clinical psychotic symptoms (psychosis-like symptoms) in children is not known. AIMS: To explore the associations of body size at birth and age 7.5 years with childhood psychosis-like symptoms. METHOD: Prospective cohort of children followed up from birth to age 12: the ALSPAC cohort. RESULTS: Data on 6000 singleton infants born after 37 weeks of gestation. A one standard deviation increase in birth weight was associated with an 18% reduction in the risk of definite psychosis-like symptoms after adjusting for age and gestation (Odds ratio (OR) = 0.82, 95% CI = 0.73-0.92, P = 0.001). This association was partly confounded by maternal anthropometry, smoking during pregnancy, socioeconomic status and IQ. A similar association was seen for birth length and psychosis-like symptoms, which disappeared after controlling for birth weight. There was little evidence for an association of 7-year height or adiposity with psychosis-like symptoms. CONCLUSIONS: Measures of impaired fetal, but not childhood, growth are associated with an increased risk of psychosis-like symptoms in 12-year-olds.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transtornos Psicóticos
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Desenvolvimento Infantil
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Desenvolvimento Fetal
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Crescimento
Tipo de estudo:
Diagnostic_studies
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Etiology_studies
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Risk_factors_studies
Limite:
Child
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Female
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Humans
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Male
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Newborn
País/Região como assunto:
Europa
Idioma:
En
Revista:
Br J Psychiatry
Ano de publicação:
2009
Tipo de documento:
Article