Alzheimer patients and Down patients: abnormal presynaptic terminals are related to cerebral preamyloid deposits.
Neurosci Lett
; 119(1): 56-9, 1990 Oct 30.
Article
em En
| MEDLINE
| ID: mdl-1965862
ABSTRACT
In Alzheimer's disease, in Down syndrome and in normal aging, scattered deposits of amyloid fibril precursors occur in both cerebral cortex and subcortical grey structures. Within such preamyloid deposits, no degenerating neurites with paired helical filaments have ever been observed. This study, carried out on brains from Alzheimer patients and Down patients, reports on the relationship between preamyloid deposits and neuritic changes. These changes were represented by presynaptic terminal swellings immunolabeled by antisynaptophysin and antiubiquitin antibodies, not by Alz50. These findings support the view that the deposition of amyloid fibril precursors in the neuropil is closely related to presynaptic terminals, although whether the former precedes or follows the development of presynaptic terminal changes is still undetermined.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sinapses
/
Encéfalo
/
Síndrome de Down
/
Doença de Alzheimer
/
Amiloide
Limite:
Adult
/
Aged
/
Aged80
/
Humans
Idioma:
En
Revista:
Neurosci Lett
Ano de publicação:
1990
Tipo de documento:
Article
País de afiliação:
Itália