[Gene therapy for myeloid leukemia].

ABSTRACT

Among several immune-gene therapies against myeloid leukemia, "T cell depleted haplo-identical transplantation with HSV-TK gene modified T cell add-back" and "donor lymphocyte infusion using HSV-TK gene modified T cell in patients experiencing recurrence after allogeneic stem cell transplantation" were in advanced stages of clinical development. In this chapter, I will summarize the strategies of gene therapy using HSV-TK gene modified T lymphocyte in allogeneic stem cell transplantation. I will also point out the current situation of other gene therapies such as cytokine gene modified CML-DC and TCR gene modified T lymphocyte against myeloid leukemia.