Cell therapy strategies and improvements for muscular dystrophy.
Cell Death Differ
; 17(8): 1222-9, 2010 Aug.
Article
em En
| MEDLINE
| ID: mdl-19876070
ABSTRACT
Understanding stem cell commitment and differentiation is a critical step towards clinical translation of cell therapies. In past few years, several cell types have been characterized and transplanted in animal models for different diseased tissues, eligible for a cell-mediated regeneration. Skeletal muscle damage is a challenge for cell- and gene-based therapeutical approaches, given the unique architecture of the tissue and the clinical relevance of acute damages or dystrophies. In this review, we will consider the regenerative potential of embryonic and somatic stem cells and the outcomes achieved on their transplantation into animal models for muscular dystrophy or acute muscle impairment.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transplante de Células-Tronco
/
Distrofias Musculares
Limite:
Animals
Idioma:
En
Revista:
Cell Death Differ
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Bélgica