A profusion of upstream open reading frame mechanisms in polyamine-responsive translational regulation.
Nucleic Acids Res
; 38(2): 353-9, 2010 Jan.
Article
em En
| MEDLINE
| ID: mdl-19920120
ABSTRACT
In many eukaryotic mRNAs one or more short 'upstream' open reading frames, uORFs, precede the initiator of the main coding sequence. Upstream ORFs are functionally diverse as illustrated by their variety of features in polyamine pathway biosynthetic mRNAs. Their propensity to act as sensors for regulatory circuits and to amplify the signals likely explains their occurrence in most polyamine pathway mRNAs. The uORF-mediated polyamine responsive autoregulatory circuits found in polyamine pathway mRNAs exemplify the translationally regulated dynamic interface between components of the proteome and metabolism.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Poliaminas
/
Biossíntese de Proteínas
/
Regulação da Expressão Gênica
/
Fases de Leitura Aberta
Limite:
Animals
Idioma:
En
Revista:
Nucleic Acids Res
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Estados Unidos