New vaccines against tuberculosis.
Clin Chest Med
; 30(4): 811-26, x, 2009 Dec.
Article
em En
| MEDLINE
| ID: mdl-19925969
ABSTRACT
The only currently licensed tuberculosis (TB) vaccine, bacille Calmette Guérin, confers incomplete protection against tuberculosis, and is not safe in infants infected with the human immunodeficiency virus. A new, safe vaccine regimen, which better protects against lung disease, is urgently needed to control TB in high-burden countries. Multiple candidate vaccines have shown promise in preclinical studies, and are now entering phase 1 to 2B clinical trials. This article discusses progress in the field and issues surrounding safety, reactogenicity, immunogenicity, and efficacy testing of new TB vaccines.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tuberculose
/
Vacina BCG
/
Adjuvantes Imunológicos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Clin Chest Med
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Suíça