[The specific features of kallikrein-kinin system functioning in reproductive-aged women with hypertensive disease].

ABSTRACT

The performed clinical and biochemical study evaluated the specific features of kallikrein-kinin system (KKS) functioning in reproductive-aged women in health and in early hypertensive disease. The major molecular mechanism responsible for early hypertensive disease in young women was shown to be activation of the renin-angiotension-aldosterone system due to enhanced kininogenesis. These alterations in KKS performance were followed by the structural changes in vascular wall connective tissue, which was evident in endothelial dysfunction and which was a morphological basis for development of the major clinical signs of hypertensive disease.