Synthesis and characterization of an epimer of tacrolimus, an immunosuppressive drug.
J Nat Prod
; 73(4): 776-9, 2010 Apr 23.
Article
em En
| MEDLINE
| ID: mdl-20166703
ABSTRACT
8-Epitacrolimus (2), a new l-pipecolic acid macrolide lactone, was obtained by base-catalyzed epimerization of tacrolimus (FK-506, 1), an important immunosuppressive drug, and its structure determined by a single-crystal X-ray diffraction method. The compound was fully characterized by spectroscopic techniques. The epimer is of importance due to its potential biological effects as well as because of its possible formation during formulation, handling, and use of tacrolimus products.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tacrolimo
/
Imunossupressores
Idioma:
En
Revista:
J Nat Prod
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Dinamarca