Inhibition of growth and pulmonary metastasis of B16-F10 murine melanoma by N-1554, a polyprenyl phosphate.
Cancer Lett
; 57(2): 159-63, 1991 May 01.
Article
em En
| MEDLINE
| ID: mdl-2025888
ABSTRACT
Antitumor effect of N-1554 (alpha-dihydrodecaprenyl phosphate containing eight trans internal isoprene residues) against B16-F10 melanoma in syngeneic C57BL/6 mice was examined. B16-F10 cells were inoculated into the footpad of mice and N-1554 was intraperitoneally administered after the inoculation. The drug significantly inhibited the tumor growth in the footpad and dramatically reduced the pulmonary metastasis from the tumor. The antitumor effect of N-1554 was almost abolished when the immunosuppressant carrageenan or anti-asialo GM1 antibody was administered to mice. In addition, pretreatment of host mice with N-1554 reduced the growth of subcutaneously inoculated B16-F10 melanoma. These results suggest that enhancement of host immune system may be involved in the antitumor effect of N-1554.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fosfatos de Poli-Isoprenil
/
Gangliosídeo G(M1)
/
Melanoma
/
Antineoplásicos
Limite:
Animals
Idioma:
En
Revista:
Cancer Lett
Ano de publicação:
1991
Tipo de documento:
Article
País de afiliação:
Japão