Ryanodine contracture: a potentially specific in vitro diagnostic test for malignant hyperthermia.
Br J Anaesth
; 66(5): 611-3, 1991 May.
Article
em En
| MEDLINE
| ID: mdl-2031823
ABSTRACT
In vitro contracture tests used currently for malignant hyperthermia (MH) do not possess absolute specificity. This is potentially a great problem in the study of the genetic approach which offers the best prospect for the development of a non-invasive diagnostic test for the condition. The calcium release channel of the sarcoplasmic reticulum has been proposed as the site of the MH defect. Ryanodine, which binds avidly to this channel, was shown to differentiate between muscle of MH susceptible and normal patients in terms of in vitro contracture response. This ryanodine contracture response is proposed as a potentially specific in vitro diagnostic test for MH.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Rianodina
/
Hipertermia Maligna
/
Contração Muscular
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
Idioma:
En
Revista:
Br J Anaesth
Ano de publicação:
1991
Tipo de documento:
Article