ATPase family AAA domain-containing 3A is a novel anti-apoptotic factor in lung adenocarcinoma cells.
J Cell Sci
; 123(Pt 7): 1171-80, 2010 Apr 01.
Article
em En
| MEDLINE
| ID: mdl-20332122
ABSTRACT
AAA domain-containing 3A (ATAD3A) is a member of the AAA-ATPase family. Three forms of ATAD3 have been identified ATAD3A, ATAD3B and ATAD3C. In this study, we examined the type and expression of ATAD3 in lung adenocarcinoma (LADC). Expression of ATAD3A was detected by reverse transcription-polymerase chain reaction, immunoblotting, immunohistochemistry and confocal immunofluorescent microscopy. Our results show that ATAD3A is the major form expressed in LADC. Silencing of ATAD3A expression increased mitochondrial fragmentation and cisplatin sensitivity. Serum deprivation increased ATAD3A expression and drug resistance. These results suggest that ATAD3A could be an anti-apoptotic marker in LADC.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Adenocarcinoma
/
Apoptose
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Adenosina Trifosfatases
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Proteínas Mitocondriais
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Proteínas Reguladoras de Apoptose
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Neoplasias Pulmonares
/
Proteínas de Membrana
Tipo de estudo:
Prognostic_studies
Limite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
J Cell Sci
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Taiwan