Anthracycline-induced cardiac toxicity more likely in underweight childhood cancer survivors.
J Pediatr Hematol Oncol
; 32(5): 411-5, 2010 Jul.
Article
em En
| MEDLINE
| ID: mdl-20495481
ABSTRACT
BACKGROUND:
We did a retrospective medical record and echocardiogram review of patients with history of anthracyclines and/or radiation seen in a long-term survivor clinic from 2000-2007. OBSERVATIONS Three hundred eight out of three hundred seventy (83.2%) patients had received at least 1 screening echocardiogram, and 24/308 (7.8%) patients had an abnormal echocardiogram. Observed risk factors for a future abnormal echocardiogram included anthracycline dose > or =250 mg/m2 and underweight status (BMI <5th%) at follow-up. Age, gender, radiation, anthracycline type, history of relapse, and history of stem cell transplant were not risk factors.CONCLUSIONS:
Our results confirm the dose-dependent risk of anthracyclines, and describe a novel association with underweight status.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Magreza
/
Sobreviventes
/
Antraciclinas
/
Coração
/
Cardiopatias
/
Antibióticos Antineoplásicos
/
Neoplasias
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Idioma:
En
Revista:
J Pediatr Hematol Oncol
Assunto da revista:
HEMATOLOGIA
/
NEOPLASIAS
/
PEDIATRIA
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Estados Unidos