Aptamer-based molecular recognition for biosensor development.
Anal Bioanal Chem
; 398(6): 2471-80, 2010 Nov.
Article
em En
| MEDLINE
| ID: mdl-20644915
ABSTRACT
Nucleic acid aptamers are an emerging class of synthetic ligands and have recently attracted significant attention in numerous fields. One is in biosensor development. In principle, nucleic acid aptamers can be discovered to recognize any molecule of interest with high affinity and specificity. In addition, unlike most ligands evolved in nature, synthetic nucleic acid aptamers are usually tolerant of harsh chemical, physical, and biological conditions. These distinguished characteristics make aptamers attractive molecular recognition ligands for biosensing applications. This review first concisely introduces methods for aptamer discovery including upstream selection and downstream truncation, then discusses aptamer-based biosensor development from the viewpoint of signal production.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Técnicas Biossensoriais
/
Aptâmeros de Nucleotídeos
Idioma:
En
Revista:
Anal Bioanal Chem
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Estados Unidos