Differential effects of stress on [¹¹C]raclopride and [¹¹C]MNPA binding to striatal D2/D3 dopamine receptors: a PET study in conscious monkeys.
Synapse
; 65(1): 84-9, 2011 Jan.
Article
em En
| MEDLINE
| ID: mdl-20687105
ABSTRACT
It has been reported that stress and facilitation of dopamine neuronal system are closely related. In the present study, the effects of stress on the binding of antagonist-based [¹¹C]raclopride and agonist-based (R)-2-CH3O-N-n- propylnorapomorphine ([¹¹C]MNPA) to D2/D3 receptors were evaluated in the striatum of conscious monkey brain. The stress state assessed from plasma cortisol level was negatively correlated with [¹¹C]raclopride binding as expected. It was noteworthy that [¹¹C]MNPA binding exhibited a positive correlation with stress state; thus, the animals with higher cortisol levels showed higher binding to D2/D3 receptors.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estresse Fisiológico
/
Radioisótopos de Carbono
/
Apomorfina
/
Receptores de Dopamina D2
/
Racloprida
/
Receptores de Dopamina D3
Limite:
Animals
Idioma:
En
Revista:
Synapse
Assunto da revista:
NEUROLOGIA
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Japão