Simian immunodeficiency virus-specific CD4+ T cells from successful vaccinees target the SIV Gag capsid.
Immunogenetics
; 62(10): 701-7, 2010 Oct.
Article
em En
| MEDLINE
| ID: mdl-20812010
ABSTRACT
We recently demonstrated that vaccinated rhesus macaques controlled viral replication of a heterologous SIV challenge. Here, we analyzed anamnestic SIV-specific CD4+ T-cell responses expanding immediately after challenge and show that successful vaccinees consistently targeted a short region of the Gag-p27 Capsid (amino acids 249-291). We have also defined the major histocompatibility complex class II (MHC-II) restricting alleles for several of these responses and show that DQ-restricted CD4+ T-cells depend on unique combinations of both the DQA and DQB alleles. Analysis of SIV-specific CD4+ T-cell responses elicited by a successful vaccine may have important implications in the understanding of vaccine design.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Linfócitos T CD4-Positivos
/
Produtos do Gene gag
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Subpopulações de Linfócitos T
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Vírus da Imunodeficiência Símia
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Vacinas contra a SAIDS
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Macaca mulatta
Limite:
Animals
Idioma:
En
Revista:
Immunogenetics
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Estados Unidos