Sensitive nicotinic and mixed nicotinic-muscarinic receptors in insect neurosecretory cells.
Brain Res
; 533(1): 132-6, 1990 Nov 12.
Article
em En
| MEDLINE
| ID: mdl-2085724
Short-term cultured dorsal unpaired median neurones from adult cockroach, Periplaneta americana, have been used to study alpha-bungarotoxin-resistant cholinergic receptors. Both acetylcholine and nicotine applied by pressure ejection to the neuronal soma induced depolarizing responses recorded with the patch-clamp technique in the whole cell recording configuration. Nicotine was more potent than acetylcholine and developed a dose-dependent biphasic depolarization including a fast and a slow component. The slow component was sensitive to alpha-bungarotoxin, d-tubocurarine, pirenzepine and gallamine, whereas the fast component was resistant to these nicotinic and muscarinic antagonists. These results demonstrate that two distinct functional receptors exist: a sensitive nicotinic and a 'mixed' (nicotinic muscarinic) receptor governing a nicotine-induced biphasic response.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Periplaneta
/
Receptores Nicotínicos
/
Receptores Muscarínicos
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
Idioma:
En
Revista:
Brain Res
Ano de publicação:
1990
Tipo de documento:
Article
País de afiliação:
França