Isotretinoin plus clindamycin seem highly effective against severe erlotinib-induced skin rash in advanced non-small cell lung cancer.
J Thorac Oncol
; 5(10): 1662-3, 2010 Oct.
Article
em En
| MEDLINE
| ID: mdl-20871265
ABSTRACT
INTRODUCTION:
Erlotinib is useful in advanced non-small cell lung cancer although compliance and efficacy are diminished by skin rash in a high proportion of patients, often necessitating dose reduction or drug withdrawal. No effective treatment for the rash is available.METHODS:
We carried out a preliminary investigation on isotretinoin and clindamycin. Among 56 advanced lung cancer patients treated with erlotinib, 31 (53%) developed rash. Seven (35%) of the 20 G2/G3 cases agreed to treatment with clindamycin (450 mg/d, days 1-10; 300 mg/d, days 11-20) plus isotretinoin (20 mg/d, days 11-20) after being informed of the experimental nature of the combination.RESULTS:
In 6 of 7 (86%) patients, the rash resolved (G1/G0) without dose reduction; in the other patient (G3), the erlotinib dose also had to be reduced. Median time to resolution was 14 days (range 7-20 days). No rash-treatment adverse events occurred during 20 days of administration.CONCLUSIONS:
Isotretinoin plus clindamycin promises to be the first effective treatment for erlotinib rash and is being tested further.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Quinazolinas
/
Clindamicina
/
Isotretinoína
/
Carcinoma Pulmonar de Células não Pequenas
/
Exantema
/
Neoplasias Pulmonares
Limite:
Humans
Idioma:
En
Revista:
J Thorac Oncol
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Itália