Formation of γ-oxoacids and 1H-pyrrol-2(5H)-ones from α,ß-unsaturated ketones and ethyl nitroacetate.
J Org Chem
; 75(21): 7435-8, 2010 Nov 05.
Article
em En
| MEDLINE
| ID: mdl-20886821
ABSTRACT
Michael addition of ethyl nitroacetate on α,ß-unsaturated ketones followed by Nef oxidation under hydrolytic conditions yields γ-oxoacids instead of the corresponding α,δ-dioxoesters. A concerted decarboxylation step is proposed on the basis of computational results. Finally, conversion of the γ-ketoacids thus prepared into 1H-pyrrol-2(5H)-ones by reaction with primary amines under Paal-Knorr conditions is also reported.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oxigênio
/
Pirróis
/
Cetonas
/
Acetatos
/
Nitrocompostos
Idioma:
En
Revista:
J Org Chem
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Espanha