[Studies on antitumor drugs: the synthesis of N',N"-dispirotripiperaziniums].
Yao Xue Xue Bao
; 25(10): 785-9, 1990.
Article
em Zh
| MEDLINE
| ID: mdl-2099595
In order to search for new antitumor drugs, sixteen N',N"-dispirotripiperazine derivatives were synthesized from N',N"-dispirotripiperazinium dichloride dihydrochloride by substitution, acylation and Mannich reaction. Six compounds were selected for preliminary pharmacological test. The result showed that five compounds possess inhibitory action against carcinoma S37 in rats. The inhibitory activity of compounds VI and X was 55.0% and 41.9% respectively.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Piperazinas
/
Compostos de Espiro
/
Antineoplásicos
Limite:
Animals
Idioma:
Zh
Revista:
Yao Xue Xue Bao
Ano de publicação:
1990
Tipo de documento:
Article