Drosophila Boi limits Hedgehog levels to suppress follicle stem cell proliferation.
J Cell Biol
; 191(5): 943-52, 2010 Nov 29.
Article
em En
| MEDLINE
| ID: mdl-21098113
ABSTRACT
Stem cells depend on signals from cells within their microenvironment, or niche, as well as factors secreted by distant cells to regulate their maintenance and function. Here we show that Boi, a Hedgehog (Hh)-binding protein, is a novel suppressor of proliferation of follicle stem cells (FSCs) in the Drosophila ovary. Hh is expressed in apical cells, distant from the FSC niche, and diffuses to reach FSCs, where it promotes FSC proliferation. We show that Boi is expressed in apical cells and exerts its suppressive effect on FSC proliferation by binding to and sequestering Hh on the apical cell surface, thereby inhibiting Hh diffusion. Our studies demonstrate that cells distant from the local niche can regulate stem cell function through ligand sequestration, a mechanism that likely is conserved in other epithelial tissues.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células-Tronco
/
Proteínas de Transporte
/
Proteínas de Drosophila
/
Proliferação de Células
/
Drosophila
/
Proteínas Hedgehog
/
Folículo Ovariano
Limite:
Animals
Idioma:
En
Revista:
J Cell Biol
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Estados Unidos