The oligoadenylate synthetase family: an ancient protein family with multiple antiviral activities.
J Interferon Cytokine Res
; 31(1): 41-7, 2011 Jan.
Article
em En
| MEDLINE
| ID: mdl-21142819
ABSTRACT
The 2'-5' oligoadenylate synthetases (OAS) are interferon-induced antiviral enzymes that recognize virally produced dsRNA and initiate RNA destabilization through activation of RNase L within infected cells. However, recent evidence points toward several RNase L-independent pathways, through which members of the OAS family can exert antiviral activity. The crystal structure of OAS led to a novel insight into the catalytic mechanism, and revealed a remarkable similarity between OAS, Polyadenosine polymerase, and the class I CCA-adding enzyme from Archeoglobus fulgidus. This, combined with a variety of bioinformatic data, leads to the definition of a superfamily of template independent polymerases and proved that the OAS family are ancient proteins, which probably arose as early as the beginning of metazoan evolution.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
2',5'-Oligoadenilato Sintetase
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Viroses
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Regulação Enzimológica da Expressão Gênica
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Interferons
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Inativação de Vírus
Limite:
Animals
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Humans
Idioma:
En
Revista:
J Interferon Cytokine Res
Assunto da revista:
ALERGIA E IMUNOLOGIA
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Dinamarca