[Nodular regenerative hyperplasia: azathioprine-induced hepatotoxicity in a patient with Crohn's disease]. / Hiperplasia nodular regenerativa: hepatotoxicidad por azatioprina en un paciente con enfermedad de Crohn.
Gastroenterol Hepatol
; 34(1): 16-9, 2011 Jan.
Article
em Es
| MEDLINE
| ID: mdl-21168244
ABSTRACT
We report the case of a 53-year-old man with Crohn's disease who developed azathioprine-induced nodular regenerative hyperplasia of the liver. The diagnosis was suspected when abnormalities in liver function tests were observed and transabdominal ultrasonography and upper gastrointestinal endoscopy showed signs of portal hypertension. The final diagnosis was established by liver biopsy, showing the characteristic alterations in liver architecture. Outcome was favorable after treatment discontinuation, with complete normalization of liver function tests within a year. The present article describes the incidence and the main clinical characteristics of this adverse effect to thiopurines.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Azatioprina
/
Doença de Crohn
/
Doença Hepática Induzida por Substâncias e Drogas
/
Hipertensão Portal
/
Imunossupressores
/
Fígado
Limite:
Humans
/
Male
/
Middle aged
Idioma:
Es
Revista:
Gastroenterol Hepatol
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Espanha