Evidence for a defect in NADH: ubiquinone oxidoreductase (complex I) in Huntington's disease.

Parker, W D; Boyson, S J; Luder, A S; Parks, J K

Parker, W D; Boyson, S J; Luder, A S; Parks, J K.

Afiliação

Parker WD; Department of Neurology, University of Colorado School of Medicine, Denver.

Neurology ; 40(8): 1231-4, 1990 Aug.

Article em En | MEDLINE | ID: mdl-2143271

RESUMO

We evaluated electron transport chain activity in platelet mitochondria taken from HD patients. All 5 patients studied had striking depressions of NADH:ubiquinone oxidoreductase activity (complex I) (5.36 +/- 2.91 nmol/min/mg; control mean, 19.12 +/- 5.64 nmol/min/mg). Other electron transport chain activities were not significantly different from control values. HD may be caused by a mutation in 1 of the nuclear coded subunits of NADH:ubiquinone oxidoreductase.

Assuntos

Plaquetas/enzimologia; Doença de Huntington/enzimologia; Quinona Redutases/sangue; Transporte de Elétrons; Feminino; Humanos; Doença de Huntington/sangue; Doença de Huntington/genética; Masculino; Pessoa de Meia-Idade; Mitocôndrias/enzimologia; NAD(P)H Desidrogenase (Quinona); Quinona Redutases/deficiência; Valores de Referência; Fatores de Risco

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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quinona Redutases / Plaquetas / Doença de Huntington Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Female / Humans / Male / Middle aged Idioma: En Revista: Neurology Ano de publicação: 1990 Tipo de documento: Article

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