Non-mitotic functions of the Anaphase-Promoting Complex.
Semin Cell Dev Biol
; 22(6): 572-8, 2011 Aug.
Article
em En
| MEDLINE
| ID: mdl-21439391
ABSTRACT
The Anaphase-Promoting Complex or Cyclosome (APC/C) is an E3 ubiquitin ligase whose activation requires the binding of a cofactor, either Cdc20 or Cdh1. While APC/C-Cdc20 is a major player during mitotic exit, APC/C-Cdh1 plays a central role in maintaining quiescence and controlling the onset of DNA replication. In addition, APC/C-Cdh1 is essential for endoreduplication, a process in which several rounds of DNA synthesis occur without mitosis. Recent data suggest that the APC/C is also involved in differentiation and metabolism, and plays important roles in postmitotic cells such as neurons. Thus, the APC/C is not only critical for anaphase onset but also regulates many other cellular processes during G1/S or in quiescent cells.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Caderinas
/
Proteínas de Ciclo Celular
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Complexos Ubiquitina-Proteína Ligase
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Ubiquitina-Proteína Ligases
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Anáfase
/
Fuso Acromático
/
Neurônios
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Semin Cell Dev Biol
Assunto da revista:
EMBRIOLOGIA
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Espanha