The anti-inflammatory effects of ketamine: state of the art.
Acta Anaesthesiol Belg
; 62(1): 47-58, 2011.
Article
em En
| MEDLINE
| ID: mdl-21612145
ABSTRACT
Inflammation is a major component in keeping the body in homeostasis. However, an overwhelmed inflammatory response may be associated to a loss of this homeostatic status, which may lead to tissue injury or organ dysfunction. A huge number of drugs interacts with the inflammatory response in a positive, negative or "dual" manner. Among these drugs, ketamine seems to have a significant positive effect on the regulation of inflammation. This NMDA-receptor antagonist acts at different levels of inflammation, interacting with inflammatory cells recrutment, cytokins production, and inflammatory mediators regulation. The resultant effect of these interactions confers to ketamine a anti-proinflammatory effect by limiting exacerbation of systemic inflammation without affecting local healing processes. This review makes a complete overview of the immunomodulatory properties of this complex anesthetic substance.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Anti-Inflamatórios não Esteroides
/
Ketamina
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Acta Anaesthesiol Belg
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Bélgica