Mini ways to stop a virus: microRNAs and HIV-1 replication.
Future Virol
; 6(2): 209-221, 2011 Feb.
Article
em En
| MEDLINE
| ID: mdl-21701674
ABSTRACT
Cellular restriction of HIV-1 replication has traditionally been thought of as protein mediated APOBEC3G hypermutates HIV-1 genomic RNA, but is counteracted by Vif; Tetherin inhibits the release of budding virions but is counteracted by Vpu. In recent years, new evidence suggesting that miRNAs and other components of the miRNA pathway act as HIV-1 restriction factors has come to light, along with the identification of strategies that HIV-1 employs to surmount these host obstacles. In this article, we summarize and discuss the literature to date regarding the complex relationship between HIV-1 and miRNA-mediated inhibition.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Future Virol
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Estados Unidos