Harnessing memory adaptive regulatory T cells to control autoimmunity in type 1 diabetes.
J Mol Cell Biol
; 4(1): 38-47, 2012 Feb.
Article
em En
| MEDLINE
| ID: mdl-22116888
ABSTRACT
Type 1 diabetes (T1D) results from autoimmune destruction of insulin-producing ß-cells in the pancreatic islets. There is an immediate need to restore both ß-cell function and immune tolerance to control disease progression and ultimately cure T1D. Currently, there is no effective treatment strategy to restore glucose regulation in patients with T1D. FoxP3-expressing CD4(+) regulatory T cells (Tregs) are potential candidates to control autoimmunity because they play a central role in maintaining self-tolerance. However, deficiencies in either naturally occurring Tregs (nTregs) themselves and/or their ability to control pathogenic effector T cells have been associated with T1D. Here, we hypothesize that nTregs can be replaced by FoxP3(+) adaptive Tregs (aTregs), which are uniquely equipped to combat autoreactivity in T1D. Unlike nTregs, aTregs are stable and provide long-lived protection. In this review, we summarize the current understanding of aTregs and their potential for use as an immunological intervention to treat T1D.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Autoimunidade
/
Linfócitos T Reguladores
/
Diabetes Mellitus Tipo 1
Limite:
Animals
/
Humans
Idioma:
En
Revista:
J Mol Cell Biol
Assunto da revista:
BIOLOGIA MOLECULAR
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Estados Unidos