Combination therapy with BMP-2 and BMSCs enhances bone healing efficacy of PCL scaffold fabricated using the 3D plotting system in a large segmental defect model.
Biotechnol Lett
; 34(7): 1375-84, 2012 Jul.
Article
em En
| MEDLINE
| ID: mdl-22447098
ABSTRACT
The three-dimensional (3D) plotting system is a rapidly-developing scaffold fabrication method for bone tissue engineering. It yields a highly porous and inter-connective structure without the use of cytotoxic solvents. However, the therapeutic effects of a scaffold fabricated using the 3D plotting system in a large segmental defect model have not yet been demonstrated. We have tested two hypotheses whether the bone healing efficacy of scaffold fabricated using the 3D plotting system would be enhanced by bone marrow-derived mesenchymal stem cell (BMSC) transplantation; and whether the combination of bone morphogenetic protein-2 (BMP-2) administration and BMSC transplantation onto the scaffold would act synergistically to enhance bone regeneration in a large segmental defect model. The use of the combined therapy did increase bone regeneration further as compared to that with monotherapy in large segmental bone defects.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Poliésteres
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Medula Óssea
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Regeneração Óssea
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Engenharia Tecidual
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Alicerces Teciduais
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Proteína Morfogenética Óssea 2
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Células-Tronco Mesenquimais
Limite:
Animals
Idioma:
En
Revista:
Biotechnol Lett
Ano de publicação:
2012
Tipo de documento:
Article