Study on the interference of rat feed to pharmacokinetics of flavonoids.
Zhong Yao Cai
; 34(12): 1906-11, 2011 Dec.
Article
em En
| MEDLINE
| ID: mdl-22500429
ABSTRACT
OBJECTIVE:
To investigate the interference of rat feed to pharmacokinetic of flavonoids.METHODS:
Flavonoids in rat feed and plasma samples were separated by rapid resolution reversed-phase HPLC and characterized by LC-ESI-MS/MS analysis with an electrospray ionization source (ESI) and a triple quadrupole analyzer by fragmentation pattern.RESULTS:
Five Citrus flavonoids (naringin, naringenin, quercetin, hesperidin and hesperetin) and two soybean isoflavonoids (daizin,daidzein) were identified in common formula rat feed. The presence of these flavonoids in plasma from rats receiving the feed was also confirmed.CONCLUSION:
The results showed the flavonoids in animal food might interfere with pharmacological and pharmacokinetic study of foreign natural compounds. This paper could be taken as a reference to pharmacological and pharmacokinetic studies of all the related substances.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cromatografia Líquida
/
Flavanonas
/
Isoflavonas
/
Ração Animal
Limite:
Animals
Idioma:
En
Revista:
Zhong Yao Cai
Assunto da revista:
TERAPIAS COMPLEMENTARES
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
China