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Exploring the relationship between the severity of oligozoospermia and the frequencies of sperm chromosome aneuploidies.
Durak Aras, B; Aras, I; Can, C; Toprak, C; Dikoglu, E; Bademci, G; Ozdemir, M; Cilingir, O; Artan, S.
Afiliação
  • Durak Aras B; Department of Medical Genetics, Eskisehir Osmangazi University, Eskisehir, Turkey. bdurak@ogu.edu.tr
Andrologia ; 44(6): 416-22, 2012 Dec.
Article em En | MEDLINE | ID: mdl-22536802
The study was aimed to investigate the association between the degree of oligozoospermia and sperm chromosome aneuploidy frequencies in male infertility and to determine whether chromosomal profiles of sperm nuclei would be used for a supportive test before additive reproduction technics. The meiotic segregation profiles of chromosomes X, Y, 13, 18 and 21 were compared by fluorescent in-situ hybridisation (FISH) on the spermatozoa of 30 normally karyotyped oligozoospermic (10 mild, 11 moderate, nine severe) cases without Y-microdeletions, and 10 normozoospermic cases. The results showed significantly higher frequencies of chromosomes 13, 18, 21 disomies (P < 0.001) in the group of patients with moderate and severe oligozoospermia compared with the disomy frequencies of normozoospermic group. The statistically significant differences were also determined in disomy frequencies of sex chromosomes (XY, XX and YY) in between oligozoospermic and normozoospermic groups (P < 0.001, P < 0.001, P < 0.040, respectively). Because oligozoospermic patients are the ones consulted the most for assisted reproductive techniques, identification of sperm aneuploidy rates in men could be considered as an appropriate supportive test before the reproductive implementations. Furthermore, the patients should be counselled with respect to genetic screening results for the potential risk of aneuploid embryo and pre-implantation genetic diagnosis or prenatal diagnosis.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oligospermia / Espermatozoides / Aneuploidia Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adult / Humans / Male Idioma: En Revista: Andrologia Ano de publicação: 2012 Tipo de documento: Article País de afiliação: Turquia

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oligospermia / Espermatozoides / Aneuploidia Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adult / Humans / Male Idioma: En Revista: Andrologia Ano de publicação: 2012 Tipo de documento: Article País de afiliação: Turquia