SNP genotyping identifies new signatures of selection in a deep sample of West African Plasmodium falciparum malaria parasites.
Mol Biol Evol
; 29(11): 3249-53, 2012 Nov.
Article
em En
| MEDLINE
| ID: mdl-22688945
ABSTRACT
We used a high-density single-nucleotide polymorphism array to genotype 75 Plasmodium falciparum isolates recently collected from Senegal and The Gambia to search for signals of selection in this malaria endemic region. We found little geographic or temporal stratification of the genetic diversity among the sampled parasites. Through application of the iHS and REHH haplotype-based tests for positive selection, we found evidence of recent selective sweeps at a known drug resistance locus, at several known antigenic loci, and at several genomic regions not previously identified as sites of recent selection. We discuss the value of deep population-specific genomic analyses for identifying selection signals within sampled endemic populations of parasites, which may correspond to local selection pressures such as distinctive therapeutic regimes or mosquito vectors.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Parasitos
/
Plasmodium falciparum
/
Seleção Genética
/
Malária Falciparum
/
Polimorfismo de Nucleotídeo Único
/
Técnicas de Genotipagem
Limite:
Animals
País/Região como assunto:
Africa
Idioma:
En
Revista:
Mol Biol Evol
Assunto da revista:
BIOLOGIA MOLECULAR
Ano de publicação:
2012
Tipo de documento:
Article