Your browser doesn't support javascript.
loading
PCR amplification of CGRP II mRNA. Variable expression in tumoral and non-tumoral human thyroid.
Lasmoles, F; Minvielle, S; Cohen, R; Guliana, J M; Delehaye, M C; Segond, N; Calmettes, C; Milhaud, G; Moukhtar, M S.
Afiliação
  • Lasmoles F; UA163 CNRS, CHU St Antoine, Paris, France.
FEBS Lett ; 277(1-2): 243-6, 1990 Dec 17.
Article em En | MEDLINE | ID: mdl-2269360
Two genes code for calcitonin gene-related peptides (CGRPs). One expresses by tissue-specific alternate splicing calcitonin and CGRP I mRNAs, the other CGRP II mRNA. Calcitonin is the marker of sporadic or hereditary human medullary thyroid carcinoma (MTC). CGRP II expression is not well established in normal or tumoral thyroid. After amplification by polymerase chain reaction, CGRP I and II mRNAs were detected in six cases of MTC associated with other endocrine neoplasia (MEN IIa) and in two cases of isolated MTC. CGRP I was detected in all non-C cell tumoral thyroids (6 samples), CGRP II was barely detectable in three out of six cases. CGRP II could be a specific tumoral marker of MTC.
Assuntos
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Calcitonina / Neoplasias da Glândula Tireoide / Carcinoma / Peptídeo Relacionado com Gene de Calcitonina Limite: Humans Idioma: En Revista: FEBS Lett Ano de publicação: 1990 Tipo de documento: Article País de afiliação: França
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Calcitonina / Neoplasias da Glândula Tireoide / Carcinoma / Peptídeo Relacionado com Gene de Calcitonina Limite: Humans Idioma: En Revista: FEBS Lett Ano de publicação: 1990 Tipo de documento: Article País de afiliação: França