Potent inhibition of norovirus 3CL protease by peptidyl α-ketoamides and α-ketoheterocycles.
Bioorg Med Chem Lett
; 22(14): 4820-6, 2012 Jul 15.
Article
em En
| MEDLINE
| ID: mdl-22698498
ABSTRACT
A series of structurally-diverse α-ketoamides and α-ketoheterocycles was synthesized and subsequently investigated for inhibitory activity against norovirus 3CL protease in vitro, as well as anti-norovirus activity in a cell-based replicon system. The synthesized compounds were found to inhibit norovirus 3CL protease in vitro and to also exhibit potent anti-norovirus activity in a cell-based replicon system.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Inibidores de Proteases
/
Cisteína Endopeptidases
/
Norovirus
/
Amidas
/
Compostos Heterocíclicos
Idioma:
En
Revista:
Bioorg Med Chem Lett
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Estados Unidos