Actin cytoskeleton in cell polarity and asymmetric division during mouse oocyte maturation.
Cytoskeleton (Hoboken)
; 69(10): 727-37, 2012 Oct.
Article
em En
| MEDLINE
| ID: mdl-22753278
ABSTRACT
Mammalian oocyte maturation involves two successive rounds of extremely asymmetric cell divisions (known as polar body extrusion) to generate a functional haploid egg. Successful polar body extrusion relies on establishment of an asymmetric spindle position and cortical polarity. Decades of studies using mouse oocytes as a model have revealed critical roles for a dynamic actin cytoskeleton in this process. Here, we review the contribution of actin to the critical events during oocyte meiotic cell divisions with an emphasis on recent advances in understanding the underlying molecular and physical mechanisms.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oócitos
/
Citoesqueleto de Actina
/
Diferenciação Celular
/
Polaridade Celular
/
Divisão Celular Assimétrica
Limite:
Animals
Idioma:
En
Revista:
Cytoskeleton (Hoboken)
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Estados Unidos