Identification of direct forkhead box O1 targets involved in palmitate-induced apoptosis in clonal insulin-secreting cells using chromatin immunoprecipitation coupled to DNA selection and ligation.

Lin, H Y; Yin, Y; Zhang, J X; Xuan, H; Zheng, Y; Zhan, S S; Zhu, Y X; Han, X

Lin, H Y; Yin, Y; Zhang, J X; Xuan, H; Zheng, Y; Zhan, S S; Zhu, Y X; Han, X.

Afiliação

Lin HY; Key Laboratory of Human Functional Genomics of Jiangsu Province, Department of Biochemistry and Molecular Biology, State Key Laboratory of Reproductive Medicine, Nanjing Medical University, 140 Hanzhong Road, Nanjing, 210029, People's Republic of China.
Yin Y; Key Laboratory of Human Functional Genomics of Jiangsu Province, Department of Biochemistry and Molecular Biology, State Key Laboratory of Reproductive Medicine, Nanjing Medical University, 140 Hanzhong Road, Nanjing, 210029, People's Republic of China.
Zhang JX; Key Laboratory of Human Functional Genomics of Jiangsu Province, Department of Biochemistry and Molecular Biology, State Key Laboratory of Reproductive Medicine, Nanjing Medical University, 140 Hanzhong Road, Nanjing, 210029, People's Republic of China.
Xuan H; Key Laboratory of Human Functional Genomics of Jiangsu Province, Department of Biochemistry and Molecular Biology, State Key Laboratory of Reproductive Medicine, Nanjing Medical University, 140 Hanzhong Road, Nanjing, 210029, People's Republic of China.
Zheng Y; Key Laboratory of Human Functional Genomics of Jiangsu Province, Department of Biochemistry and Molecular Biology, State Key Laboratory of Reproductive Medicine, Nanjing Medical University, 140 Hanzhong Road, Nanjing, 210029, People's Republic of China.
Zhan SS; Key Laboratory of Human Functional Genomics of Jiangsu Province, Department of Biochemistry and Molecular Biology, State Key Laboratory of Reproductive Medicine, Nanjing Medical University, 140 Hanzhong Road, Nanjing, 210029, People's Republic of China.
Zhu YX; Key Laboratory of Human Functional Genomics of Jiangsu Province, Department of Biochemistry and Molecular Biology, State Key Laboratory of Reproductive Medicine, Nanjing Medical University, 140 Hanzhong Road, Nanjing, 210029, People's Republic of China.
Han X; Key Laboratory of Human Functional Genomics of Jiangsu Province, Department of Biochemistry and Molecular Biology, State Key Laboratory of Reproductive Medicine, Nanjing Medical University, 140 Hanzhong Road, Nanjing, 210029, People's Republic of China. hanxiao@njmu.edu.cn.

Diabetologia ; 55(10): 2703-2712, 2012 Oct.

Article em En | MEDLINE | ID: mdl-22810813

Assuntos

Apoptose/efeitos dos fármacos; Imunoprecipitação da Cromatina/métodos; DNA/genética; Fatores de Transcrição Forkhead/fisiologia; Células Secretoras de Insulina/patologia; Luciferases; Palmitatos/farmacologia; Animais; Linhagem Celular Tumoral; Diabetes Mellitus Tipo 2; Modelos Animais de Doenças; Regulação para Baixo; Proteína Forkhead Box O1; Pirofosfatase Inorgânica/genética; Pirofosfatase Inorgânica/fisiologia; Células Secretoras de Insulina/efeitos dos fármacos; Insulinoma/patologia; Camundongos; Camundongos Endogâmicos; Fatores de Crescimento Neural/genética; Fatores de Crescimento Neural/fisiologia; Neoplasias Pancreáticas/patologia; Fatores de Transcrição/genética; Fatores de Transcrição/fisiologia; Regulação para Cima

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Palmitatos / DNA / Apoptose / Imunoprecipitação da Cromatina / Células Secretoras de Insulina / Fatores de Transcrição Forkhead / Luciferases Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals Idioma: En Revista: Diabetologia Ano de publicação: 2012 Tipo de documento: Article

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