Your browser doesn't support javascript.
loading
[Analysis of adherence and efficiency when replacing an antiretroviral therapy with efavirenz-emtricitabine-tenofovir in a single daily dose]. / Análisis del cambio en la adherencia y eficiencia del tratamiento antirretroviral con el uso de efavirenz-emtricitabina-tenofovir en dosis única diaria.
García-Ramos, S E; Santolaya Perrín, M R; Fernández-Pacheco García-Valdecasas, M.
Afiliação
  • García-Ramos SE; Servicio de Farmacia, Hospital Universitario Príncipe de Asturias, Madrid, España. silvia_garcia80@hotmail.com
Farm Hosp ; 36(5): 315-20, 2012.
Article em Es | MEDLINE | ID: mdl-22858089
ABSTRACT

OBJECTIVE:

To analyse whether the change of antiretroviral therapy to efavirenz/emtricitabine/tenofovir in a single daily dose (EETu) increases adherence and maintains effectiveness, and establish the cost increase caused by the change.

METHODS:

An observational, retrospective, and intra-subject study, performed in the outpatient dispensing unit. The study period was 1 year (6 months before and 6 months after the change). Computer dispensing records and days of hospitalisation during the study period were reviewed, and the difference in treatment adherence calculated. To determine the effectiveness of treatment, viral load and CD4 lymphocytes data before and after the change were reviewed. The cost before and after treatment for each patient was determined, and therefore the annual cost increase and the incremental cost per patient.

RESULTS:

The study included 127 patients. The difference in adherence was 0.6%. The percentage of poor adherence was 35.4% and 40.9% before and after the treatment change, respectively. The levels of CD4 lymphocytes and viral load did not change significantly with treatment. The economic analysis revealed an annual increase of 25,374.60 and €199.80 per patient.

CONCLUSIONS:

The use of EETu did not improve the control of HIV infection in terms of effectiveness and adherence, and resulted in increased economic costs. Therefore, its choice as antiretroviral treatment will have to be based on criteria other than those described above.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oxazinas / Adenina / Infecções por HIV / Cooperação do Paciente / Fármacos Anti-HIV / Terapia Antirretroviral de Alta Atividade / Desoxicitidina / Organofosfonatos Limite: Adult / Female / Humans / Male / Middle aged País/Região como assunto: Europa Idioma: Es Revista: Farm Hosp Assunto da revista: FARMACIA / HOSPITAIS Ano de publicação: 2012 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oxazinas / Adenina / Infecções por HIV / Cooperação do Paciente / Fármacos Anti-HIV / Terapia Antirretroviral de Alta Atividade / Desoxicitidina / Organofosfonatos Limite: Adult / Female / Humans / Male / Middle aged País/Região como assunto: Europa Idioma: Es Revista: Farm Hosp Assunto da revista: FARMACIA / HOSPITAIS Ano de publicação: 2012 Tipo de documento: Article