Nanophotosensitizers toward advanced photodynamic therapy of Cancer.
Cancer Lett
; 334(2): 176-87, 2013 Jul 01.
Article
em En
| MEDLINE
| ID: mdl-23017942
ABSTRACT
UNLABELLED Photodynamic therapy (PDT) is a non-invasive treatment modality for selective destruction of cancer and other diseases and involves the colocalization of light, oxygen, and a photosensitizer (PS) to achieve photocytotoxicity. Although this therapeutic method has considerably improved the quality of life and life expectancy of cancer patients, further advances in selectivity and therapeutic efficacy are required to overcome numerous side effects related to classical PDT. The application of nanoscale photosensitizers (NPSs) comprising molecular PSs and nanocarriers with or without other biological/photophysical functions is a promising approach for improving PDT. In this review, we focus on four nanomedical approaches for advanced PDT (1) nanocarriers for targeted delivery of PS, (2) introduction of active targeting moieties for disease-specific PDT, (3) stimulus-responsive NPSs for selective PDT, and (4) photophysical improvements in NPS for enhanced PDT efficacy. HIGHLIGHTS ⺠Conservation of normal tissues demands non-invasive therapeutic methods. ⺠PDT is a light-activated, non-invasive modality for selective destruction of cancers.⺠Success of PDT requires further advances to overcome the limitations of classical PDT. âºNanophotosensitizers help improve target selectivity and therapeutic efficacy of PDT.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fotoquimioterapia
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Fármacos Fotossensibilizantes
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Nanomedicina
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Nanopartículas
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Neoplasias
Limite:
Animals
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Humans
Idioma:
En
Revista:
Cancer Lett
Ano de publicação:
2013
Tipo de documento:
Article