Involvement of glucocorticoid receptor on hyperpyrexia  induced by methamphetamine administration.

Yoshida, S; Kinoshita, H; Tatara, T; Tashiro, C; Nishiguchi, M; Ouchi, H; Minami, T; Hishida, S

Involvement of glucocorticoid receptor on hyperpyrexia induced by methamphetamine administration.

Yoshida, S; Kinoshita, H; Tatara, T; Tashiro, C; Nishiguchi, M; Ouchi, H; Minami, T; Hishida, S.

Afiliação

Yoshida S; Department of Anesthesia, Hyogo College of Medicine, Nishinomiya, Japan.

Soud Lek ; 57(4): 66-8, 2012 Oct.

Article em En | MEDLINE | ID: mdl-23121037

ABSTRACT

ABSTRACT

UNLABELLED We have investigated the involvement of glucocorticoid on methamphetamine (MA) induced hyperpyrexia using a bio-telemetric system. A significant level of hyperpyrexia was observed in MA administered rats. In contrast, increase of body temperature was suppressed by adrenalectomy or by the administration of RU-486, an antagonist of the glucocorticoid receptor. These data suggest that the glucocorticoid receptor may be involved in hyperpyrexia induced by MA. KEYWORDS methamphetamine - hyperpyrexia - glucocorticoid - corticosterone.

Assuntos

Estimulantes do Sistema Nervoso Central/intoxicação; Febre/induzido quimicamente; Metanfetamina/intoxicação; Receptores de Glucocorticoides/metabolismo; Adrenalectomia; Animais; Temperatura Corporal/efeitos dos fármacos; Corticosterona/sangue; Masculino; Mifepristona/farmacologia; Ratos; Ratos Wistar

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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores de Glucocorticoides / Febre / Estimulantes do Sistema Nervoso Central / Metanfetamina Limite: Animals Idioma: En Revista: Soud Lek Ano de publicação: 2012 Tipo de documento: Article País de afiliação: Japão

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