Involvement of glucocorticoid receptor on hyperpyrexia induced by methamphetamine administration.
Soud Lek
; 57(4): 66-8, 2012 Oct.
Article
em En
| MEDLINE
| ID: mdl-23121037
ABSTRACT
UNLABELLED We have investigated the involvement of glucocorticoid on methamphetamine (MA) induced hyperpyrexia using a bio-telemetric system. A significant level of hyperpyrexia was observed in MA administered rats. In contrast, increase of body temperature was suppressed by adrenalectomy or by the administration of RU-486, an antagonist of the glucocorticoid receptor. These data suggest that the glucocorticoid receptor may be involved in hyperpyrexia induced by MA. KEYWORDS methamphetamine - hyperpyrexia - glucocorticoid - corticosterone.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Receptores de Glucocorticoides
/
Febre
/
Estimulantes do Sistema Nervoso Central
/
Metanfetamina
Limite:
Animals
Idioma:
En
Revista:
Soud Lek
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Japão