Drosophila H1 regulates the genetic activity of heterochromatin by recruitment of Su(var)3-9.
Science
; 340(6128): 78-81, 2013 Apr 05.
Article
em En
| MEDLINE
| ID: mdl-23559249
ABSTRACT
Eukaryotic genomes harbor transposable elements and other repetitive sequences that must be silenced. Small RNA interference pathways play a major role in their repression. Here, we reveal another mechanism for silencing these sequences in Drosophila. Depleting the linker histone H1 in vivo leads to strong activation of these elements. H1-mediated silencing occurs in combination with the heterochromatin-specific histone H3 lysine 9 methyltransferase Su(var)3-9. H1 physically interacts with Su(var)3-9 and recruits it to chromatin in vitro, which promotes H3 methylation. We propose that H1 plays a key role in silencing by tethering Su(var)3-9 to heterochromatin. The tethering function of H1 adds to its established role as a regulator of chromatin compaction and accessibility.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas Repressoras
/
Heterocromatina
/
Histonas
/
Sequências Repetitivas de Ácido Nucleico
/
Inativação Gênica
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Proteínas de Drosophila
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Drosophila melanogaster
Limite:
Animals
Idioma:
En
Revista:
Science
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Estados Unidos