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Physiological adaptations to reproduction. I. Experimentally increasing litter size enhances aspects of antioxidant defence but does not cause oxidative damage in mice.
Garratt, Michael; Pichaud, Nicolas; King, Edith D Aloise; Brooks, Robert C.
Afiliação
  • Garratt M; Evolution and Ecology Research Centre and School of Biological, Earth and Environmental Sciences, The University of New South Wales, Sydney, New South Wales 2052, Australia. Michael.Garratt@unsw.edu.au
J Exp Biol ; 216(Pt 15): 2879-88, 2013 Aug 01.
Article em En | MEDLINE | ID: mdl-23619417
ABSTRACT
Life history theory suggests that investment in reproduction can trade off against growth, longevity and both reproduction and performance later in life. One possible reason for this trade-off is that reproduction directly causes somatic damage. Oxidative stress, an overproduction of reactive oxygen species in relation to cellular defences, can correlate with reproductive investment and has been implicated as a pathway leading to senescence. This has led to the suggestion that this aspect of physiology could be an important mechanism underlying the trade-off between reproduction and lifespan. We manipulated female reproductive investment to test whether oxidative stress increases with reproduction in mice. Each female's pups were cross-fostered to produce litters of either two or eight, representing low and high levels of reproductive investment for wild mice. No differences were observed between reproductive groups at peak lactation for several markers of oxidative stress in the heart and gastrocnemius muscle. Surprisingly, oxidative damage to proteins was lower in the livers of females with a litter size of eight than in females with two pups or non-reproductive control females. While protein oxidation decreased, activity levels of the antioxidant enzyme superoxide dismutase increased in the liver, suggesting this may be one pathway used to protect against oxidative stress. Our results highlight the need for caution when interpreting correlative relationships and suggest that oxidative stress does not increase with enhanced reproductive effort during lactation.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Reprodução / Adaptação Fisiológica / Estresse Oxidativo / Tamanho da Ninhada de Vivíparos / Antioxidantes Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: J Exp Biol Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Austrália

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Reprodução / Adaptação Fisiológica / Estresse Oxidativo / Tamanho da Ninhada de Vivíparos / Antioxidantes Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: J Exp Biol Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Austrália