Existence of antigen-specific immunoglobulin E is not sufficient for allergic nasal eosinophil infiltration in mice.
Int Arch Allergy Immunol
; 161 Suppl 2: 125-8, 2013.
Article
em En
| MEDLINE
| ID: mdl-23711863
ABSTRACT
BACKGROUND:
Immunoglobulin E (IgE) is important for the development of allergic rhinitis (AR), though the contribution of IgE to the infiltration of eosinophils in the nasal mucosa has not been fully elucidated. In this study, antigen-induced sneezing and nasal eosinophil accumulation were comparatively investigated in anti-ovalbumin (OVA)-IgE transgenic (Tg) and wild-type (WT) mice.METHODS:
Tg and OVA-immunized WT mice were intranasally challenged with OVA. Antigen-specific serum IgE level, sneezing and infiltration of eosinophil into the nasal cavity were then examined.RESULTS:
The level of serum OVA-specific IgE in Tg mice was significantly higher than that in antigen-immunized WT mice. Compared to saline challenge, intranasal challenge with OVA significantly induced sneezing in both Tg and immunized WT mice. However, antigen-induced nasal eosinophil infiltration was observed in immunized WT mice but not in Tg mice.CONCLUSIONS:
IgE-mediated responses might not play a crucial role in antigen-induced eosinophil infiltration in AR.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Imunoglobulina E
/
Eosinófilos
/
Hipersensibilidade
/
Antígenos
/
Mucosa Nasal
Limite:
Animals
Idioma:
En
Revista:
Int Arch Allergy Immunol
Assunto da revista:
ALERGIA E IMUNOLOGIA
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Japão