Synthesis and biological evaluation of 3-(4-chlorophenyl)-4-substituted pyrazole derivatives.
Org Biomol Chem
; 11(29): 4891-8, 2013 Aug 07.
Article
em En
| MEDLINE
| ID: mdl-23779132
ABSTRACT
3-(4-Chlorophenyl)-4-substituted pyrazole derivatives were synthesised and tested for their in vitro antifungal activity. Some compounds showed very good antifungal activity against four pathogenic strains of fungi. The same compounds exhibited an interesting activity against the tested strain of Mycobacterium tuberculosis H37Rv. The results suggest that 1,3,4-oxadiazoles and 5-pyrazolinones bearing a core pyrazole scaffold may be promising antifungal and antitubercular agents.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pirazóis
/
Aspergillus
/
Candida
/
Cryptococcus neoformans
/
Mycobacterium tuberculosis
/
Antifúngicos
Idioma:
En
Revista:
Org Biomol Chem
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Reino Unido