Unusual tubulin-clustering ability of specifically c7-modified colchicine analogues.
Chembiochem
; 14(12): 1444-9, 2013 Aug 19.
Article
em En
| MEDLINE
| ID: mdl-23843347
ABSTRACT
Highly cytotoxic C7-modified colchicine analogues, exemplified by tubuloclustin, promote microtubule disassembly followed by the formation of very stable tubulin clusters, both in vitro and in cells. The proposed mechanism of action of tubuloclustin and its analogues, beyond that of colchicine, includes additional specific interactions with the α-tubulin subunit.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tubulina (Proteína)
/
Adamantano
/
Colchicina
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Chembiochem
Assunto da revista:
BIOQUIMICA
Ano de publicação:
2013
Tipo de documento:
Article