Identification of an age-dependent biomarker signature in children and adolescents with autism spectrum disorders.
Mol Autism
; 4(1): 27, 2013 Aug 06.
Article
em En
| MEDLINE
| ID: mdl-23915542
ABSTRACT
BACKGROUND:
Autism spectrum disorders (ASDs) are neurodevelopmental conditions with symptoms manifesting before the age of 3, generally persisting throughout life and affecting social development and communication. Here, we have investigated changes in protein biomarkers in blood during childhood and adolescent development.METHODS:
We carried out a multiplex immunoassay profiling analysis of serum samples from 37 individuals with a diagnosis of ASD and their matched, non-affected siblings, aged between 4 and 18 years, to identify molecular pathways affected over the course of ASDs.RESULTS:
This analysis revealed age-dependent differences in the levels of 12 proteins involved in inflammation, growth and hormonal signaling.CONCLUSIONS:
These deviations in age-related molecular trajectories provide further insight into the progression and pathophysiology of the disorder and, if replicated, may contribute to better classification of ASD individuals, as well as to improved treatment and prognosis. The results also underline the importance of stratifying and analyzing samples by age, especially in ASD and potentially other developmental disorders.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Diagnostic_studies
Idioma:
En
Revista:
Mol Autism
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Reino Unido