Constitutive expression of ligand for natural killer cell NKp44 receptor (NKp44L) by normal human articular chondrocytes.
Cell Immunol
; 285(1-2): 6-9, 2013.
Article
em En
| MEDLINE
| ID: mdl-24044960
ABSTRACT
Normal chondrocytes display susceptibility to lysis by natural killer (NK) cells and this phenomenon may play a role in some inflammatory cartilage disorders. The mechanisms of chondrocyte recognition and killing by NK cells remain unclear. Using flow cytometry and immunohistochemical staining we found that normal human articular chondrocytes constitutively express a ligand for NKp44, one of stimulatory NK cell receptors involved in recognition and killing of target cells. Expression of NKp44 ligand by normal articular chondrocytes is not involved in their killing by unstimulated NK cells; however, it is responsible for anti-chondrocyte cytotoxicity mediated by long-term activated NK cells. Thus, expression of NKp44 ligand may play a role in chondrocyte destruction in course of chronic inflammatory cartilage disorders.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células Matadoras Naturais
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Cartilagem
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Condrócitos
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Receptor 2 Desencadeador da Citotoxicidade Natural
Limite:
Child
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Child, preschool
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Humans
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Infant
Idioma:
En
Revista:
Cell Immunol
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
França