[Action of aminoglycosides on platelet aggregation in vitro]. / L'azione degli aminoglicosidi sulla aggregazione piastrinica in vitro.
Boll Soc Ital Biol Sper
; 61(3): 357-63, 1985 Mar 30.
Article
em It
| MEDLINE
| ID: mdl-2411277
ABSTRACT
The authors tested the influence of gentamicin, spectinomycin dihydrostreptomycin on the ADP and epinephrine in vitro induced platelet aggregation. Our aim was to demonstrate if platelet aggregation in vitro had some influences by antibiotics. A reduction in platelet aggregability, strictly dependent from the used antibiotic dose was observed. We have studied platelet function thanks to Born's method, adding to PRP gradual therapeutics doses of antibiotics. The results showed a reduction of platelet function which was dose-depended, and, particularly, gentamicin seemed to be the most effective among aminoglycosides. An interference between these drugs and the ADP and epinephrine binding to specific platelet receptor sites is proposed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sulfato de Di-Hidroestreptomicina
/
Gentamicinas
/
Agregação Plaquetária
/
Espectinomicina
Limite:
Humans
Idioma:
It
Revista:
Boll Soc Ital Biol Sper
Ano de publicação:
1985
Tipo de documento:
Article