Age-related disruption of autophagy in dermal fibroblasts modulates extracellular matrix components.

Tashiro, Kanae; Shishido, Mayumi; Fujimoto, Keiko; Hirota, Yuko; Yo, Kazuyuki; Gomi, Takamasa; Tanaka, Yoshitaka

Tashiro, Kanae; Shishido, Mayumi; Fujimoto, Keiko; Hirota, Yuko; Yo, Kazuyuki; Gomi, Takamasa; Tanaka, Yoshitaka.

Afiliação

Tashiro K; Skin Research Department, POLA Chemical Industries, Inc., Yokohama, Japan; Division of Pharmaceutical Cell Biology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
Shishido M; Skin Research Department, POLA Chemical Industries, Inc., Yokohama, Japan.
Fujimoto K; Division of Pharmaceutical Cell Biology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan; Organelle Homeostasis Research Center, Kyushu University, Fukuoka, Japan.
Hirota Y; Division of Pharmaceutical Cell Biology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
Yo K; Skin Research Department, POLA Chemical Industries, Inc., Yokohama, Japan.
Gomi T; Skin Research Department, POLA Chemical Industries, Inc., Yokohama, Japan.
Tanaka Y; Division of Pharmaceutical Cell Biology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan; Organelle Homeostasis Research Center, Kyushu University, Fukuoka, Japan. Electronic address: tanakay@bioc.phar.kyushu-u.ac.jp.

Biochem Biophys Res Commun ; 443(1): 167-72, 2014 Jan 03.

Article em En | MEDLINE | ID: mdl-24287182

Assuntos

Autofagia; Matriz Extracelular/fisiologia; Fibroblastos/fisiologia; Envelhecimento da Pele; Pele/citologia; Adulto; Células Cultivadas; Feminino; Humanos; Metaloproteinase 1 da Matriz/metabolismo; Proteínas Associadas aos Microtúbulos/metabolismo; Pessoa de Meia-Idade; Fagossomos/fisiologia; Complexo de Endopeptidases do Proteassoma/fisiologia

Palavras-chave

Autophagosome; Autophagy; CMA; Dermal fibroblast; Extracellular matrix; LAMP-2A; LC3; MMP-1; chaperone-mediated autophagy; leu; leupeptin; lysosome-associated receptor protein type 2A; matrix metalloproteinase-1; microtubule-associated protein 1 light chain 3; pep; pepstatin A

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pele / Autofagia / Envelhecimento da Pele / Matriz Extracelular / Fibroblastos Limite: Adult / Female / Humans / Middle aged Idioma: En Revista: Biochem Biophys Res Commun Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Japão

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