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(E)-Alkenes as replacements of amide bonds: development of novel and potent acyclic CGRP receptor antagonists.
Kim, June J; Wood, Michael R; Stachel, Shawn J; de Leon, Pablo; Nomland, Ashley; Stump, Craig A; McWherter, Melody A; Schirripa, Kathy M; Moore, Eric L; Salvatore, Christopher A; Selnick, Harold G.
Afiliação
  • Kim JJ; Department of Medicinal Chemistry, Merck & Co., Inc., PO Box 4, 770 Sumneytown Pike, West Point, PA 19486, United States. Electronic address: june.kim@merck.com.
  • Wood MR; Department of Medicinal Chemistry, Merck & Co., Inc., PO Box 4, 770 Sumneytown Pike, West Point, PA 19486, United States.
  • Stachel SJ; Department of Medicinal Chemistry, Merck & Co., Inc., PO Box 4, 770 Sumneytown Pike, West Point, PA 19486, United States.
  • de Leon P; Department of Medicinal Chemistry, Merck & Co., Inc., PO Box 4, 770 Sumneytown Pike, West Point, PA 19486, United States.
  • Nomland A; Department of Medicinal Chemistry, Merck & Co., Inc., PO Box 4, 770 Sumneytown Pike, West Point, PA 19486, United States.
  • Stump CA; Department of Medicinal Chemistry, Merck & Co., Inc., PO Box 4, 770 Sumneytown Pike, West Point, PA 19486, United States.
  • McWherter MA; Department of Medicinal Chemistry, Merck & Co., Inc., PO Box 4, 770 Sumneytown Pike, West Point, PA 19486, United States.
  • Schirripa KM; Department of Medicinal Chemistry, Merck & Co., Inc., PO Box 4, 770 Sumneytown Pike, West Point, PA 19486, United States.
  • Moore EL; Department of Pain Research, Merck & Co., Inc., PO Box 4, 770 Sumneytown Pike, West Point, PA 19486, United States.
  • Salvatore CA; Department of Pain Research, Merck & Co., Inc., PO Box 4, 770 Sumneytown Pike, West Point, PA 19486, United States.
  • Selnick HG; Department of Medicinal Chemistry, Merck & Co., Inc., PO Box 4, 770 Sumneytown Pike, West Point, PA 19486, United States.
Bioorg Med Chem Lett ; 24(1): 258-61, 2014 Jan 01.
Article em En | MEDLINE | ID: mdl-24332093
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Alcenos / Antagonistas do Receptor do Peptídeo Relacionado ao Gene de Calcitonina Limite: Humans Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2014 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Alcenos / Antagonistas do Receptor do Peptídeo Relacionado ao Gene de Calcitonina Limite: Humans Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2014 Tipo de documento: Article