Acute liver failure associated with traditional Chinese medicine: report of 30 cases from seven tertiary hospitals in China*.
Crit Care Med
; 42(4): e296-9, 2014 Apr.
Article
em En
| MEDLINE
| ID: mdl-24335449
ABSTRACT
OBJECTIVES:
Up to now, limited cases with acute liver failure caused by traditional Chinese medicine have been reported, and thus this topic has been scarcely discussed. This study aims to report such cases from China.DESIGN:
A retrospective study.SETTING:
Clinical investigation among seven tertiary hospitals in different areas of China. PATIENTS From January 2007 to December 2012, patients with acute liver failure induced by traditional Chinese medicinal herbs were included.INTERVENTIONS:
None. MEASUREMENTS AND MAINRESULTS:
A total of 30 patients were finally identified, including six men and 24 women. The average age was 39.7 years. The median period from initial symptoms to the development of hepatic encephalopathy was 13 days. Nine patients (30%) had accepted herbal therapies due to their skin disorders before the onset of acute liver failure. Eighteen patients (60%) eventually died, 10 of whom died of heavy bleeding. No patients received liver transplantation.CONCLUSIONS:
The model of safety monitoring for traditional Chinese materia medica should be established. For those critically ill patients with herb-induced acute liver failure, coagulopathy is a vital problem in critical care. Additionally, the rate of liver transplantation for acute liver failure in China needs to be improved.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Medicamentos de Ervas Chinesas
/
Doença Hepática Induzida por Substâncias e Drogas
/
Centros de Atenção Terciária
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Asia
Idioma:
En
Revista:
Crit Care Med
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
China