[Association of polymorphism Rs6737848 in the Socs5 gene with bronchial asthma].
Vestn Ross Akad Med Nauk
; (7): 53-6, 2013.
Article
em Ru
| MEDLINE
| ID: mdl-24340963
ABSTRACT
AIM:
To investigate the role of polymorphic variants of immune-response modifying genes in predisposition to asthma. PATIENTS ANDMETHODS:
The analysis of restriction fragments length polymorphism was used to investigate 10 single-nucleotide polymorphisms IFNG rs2069705, IFNGR2 rs17880053, IL4 rs 2070874, IL4RA rs 1805010, GATA3 rs10905277, TBX21 rs11652969, PIASY rs3760903, PIAS3 rs12756687, STATS rs16967593, and SOCS5 rs6737848 in 106 asthma patients and 115 healthy people.RESULTS:
The rs6737848 SOCS5 polymorphism was significantly associated with asthma in additive model (p = 0.05, OR = 0.338, 95% CI 0.158-0.723) and in dominant model (p = 0.02, OR = 0.284, CI 0.126-0.638). None of the polymorphisms of the studied genes was associated with total IgE levels.CONCLUSIONS:
This is the first report on the association of rs6737848 SOCS5 with asthma.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polimorfismo Genético
/
Asma
/
DNA
/
Predisposição Genética para Doença
/
Proteínas Supressoras da Sinalização de Citocina
Tipo de estudo:
Risk_factors_studies
Limite:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Ru
Revista:
Vestn Ross Akad Med Nauk
Assunto da revista:
MEDICINA
Ano de publicação:
2013
Tipo de documento:
Article